Emilia Bergoglio

Emilia Bergoglio

Why not create your own Wantedly profile?

Showcase yourself and your experiences to bring your professional story to life.

Join

Always as questions

人々の生活を前向きに変えたい。科学や特に神経科学と脳機能の研究に情熱を注いでいます。暇なときはオーダーメイドテーラーです。

Apr 2017
-
Jan 2021

東京大学/とうきょうだいがく

4 years

博士

Apr 2017 - Jan 2021

Spatial and temporal diversity of DCLK1 isoforms in developing mouse brain

Doublecortin-like kinase 1 (DCLK1) is a Doublecortin family kinase involved in a range of brain development processes including cell migration, axon/dendrite growth, and synapse development. The Dclk1 gene potentially generates multiple splicing isoforms, but the detailed expression patterns in the brain as well as in vivo functions of each isoform are still incompletely understood. Here we assessed expression patterns of DCLK1 isoforms using multiple platforms including in silico, in situ, and in vitro datasets in the developing mouse brain, and show quantitative evidence that among the four DCLK1 isoforms, DCLK1-L and DCL are mainly expressed in the embryonic cortex whereas DCLK1-L and CPG16 become dominant compared to DCL and CARP in the postnatal cortex. We also provide compelling evidence that DCLK1 isoforms are distributed in the partially distinct brain regions in the embryonic and the postnatal stages. We further show that overexpression of DCLK1-L, but not the other isoforms, in neural progenitors causes severe migration defects in the cortex, and that the migration defects are dependent on the kinase activity of DCLK1-L. Our data thus uncover partially segregated localization of DCLK1 isoforms in the developing mouse brain and suggest different roles for distinct DCLK1 isoforms in the brain development and function.

Jan 2021

Spatial and temporal diversity of DCLK1 isoforms in developing mouse brain

Jan 2021

Oct 2013
-
Mar 2016

University of Trieste

3 years

MSc in Neuroscience

Oct 2013 - Mar 2016

Mar 2015
-
Jan 2016

Visiting Student Researcher

Mar 2015 - Jan 2016


Publications

Spatial and temporal diversity of DCLK1 isoforms in developing mouse brain

Jan 2021