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  • Mechanisms on receptor-mediated neurotoxicity and its prevention by pharmacological compounds

    Published several scientific papers in prestigious international journals since 2010 Abstracts and details of all published papers were enlisted below, please refer to NCBI website: http://www.ncbi.nlm.nih.gov/pubmed/?term=chang-shin+kuo ● Voltage-gated potassium channels in neonatal cortical astrocytes Role of voltage-gated K+ channels in regulating Ca2+ entry in rat cortical astrocytes (2015) ●Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine. (2014) ●Basic mechanism of aberrant endoplasmic reticulum (ER) calcium store in pancreatic beta cells is involved in voltage-gated calcium channels Down-regulation of voltage-gated Ca2+ channels in Ca2+ store-depleted rat insulinoma RINm5F cells (2013) ●analgesic effects of local anesthesia in voltage-gated sodium channels in vivo and vitro 1. The use of carbetapentane for spinal anesthesia and use-dependent block of sodium currents. (2013) 2. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. (2013) 3. Isobolographic analysis of interaction between nisoxetine- and mepivacaine-induced spinal blockades in rats. (2012) ●Natural compounds improves activation in voltage-gated sodium and potassium channels in vitro 1. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. (2012) 2. Inhibitory effects of magnolol on voltage-gated Na+ and K+ channels of NG108-15 cells. (2012) 3. Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells. (2011) 4. Arylnaphthalene lignans from Taiwania cryptomerioides as novel blockers of voltage-gated K+ channels. (2010) ●Potassium channels activation is relevant to neurite outgrowth Voltage-gated K+ channels play a role in cAMP-stimulated neuritogenesis in mouse neuroblastoma N2A cells. (2011) ●Permeability of mutated voltage-gated potassium channels Control of ionic selectivity by a pore helix residue in the Kv1.2 channel. (2010)

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